The RUMA Targets Task Force (TTF) group was conceived in Spring 2016 in response to Lord Jim O’Neill’s seminal Antimicrobial Resistance (AMR) Review. The report, commissioned by the UK government in 2014 to assess the global problem of increasing drug resistance, set a challenge to UK Agriculture to respond to the AMR challenge and contribute to the UK’s One Health effort to reduce resistance to antibiotics and protect human health. The report put forward a number of actions to address the issue, one of which was to develop industry-led, sector-specific targets for antibiotic stewardship in UK livestock farming.